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KMID : 0613820070170121717
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Journal of Life Science
2007 Volume.17 No. 12 p.1717 ~ p.1722
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The Effects of Exercise Training on Cardiac eNOS, ET-1 mRNA and Skeletal Muscle eNOS Protein Level in SHR
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Cho In-Ho
Cho Joon-Yong
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Abstract
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In the present study, all of the treadmill exercise-trained SHR expressed clear adaptive changes such as reduced resting heart rate and blood pressures, LPOA, homocysteine Therefore, treadmill exercise was sufficient to induce physiological adaptation in the SHR. Endurance training is known to induce physiological cardiac hypertrophy, while hypertension induces pathological cardiac hypertrophy that increases cardiomyocyte apoptosis. The pathological adaptation to pressure overload has also been associated with a further increase in the expression of several marker genes including cardiomyocyte ET-1 in the SHR, but not in the exercise-trained SHR. Additionally, there is an increase in the endothelial nitricoxide synthases (eNOS) protein expression of soleus, gastrocnemius, and extensor digitorum longus muscle in the exercise-trained SHR but not in the SHR in the present study. Thus, compared to pathological adaptation to pressure overload, physiological adaptation to exercise training is associated with distinct alterations in cardiac and molecular phenotypes. based on these results, exercise training improves hypertension by cardiovascular regulating genes and hemodynamic parameters.
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KEYWORD
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SHR(Spontaneously hypertensive rat), treadmill exercise, eNOS, ET-1, pathological hypertrophy
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